W. V. Quine was quite simply the most distinguished analytic philosopher of the later half of the twentieth century. His celebrated attack on the analytic/synthetic tradition heralded a major shift away from the views of language descended from logical positivism. His most important book, Word and Object, introduced the concept of indeterminacy of radical translation, a bleak view of the nature of the language with which we ascribe thoughts and beliefs to ourselves and others. Quine is also famous for the (...) view that epistemology should be naturalized, that is conducted in a scientific spirit with the object of investigating the relationship between the inputs of experience and the outputs of belief. The eleven essays in this volume cover all the central topics of Quine's philosophy: the underdetermination of physical theory, analycity, naturalism, propositional attitudes, behaviorism, reference and ontology, positivism, holism and logic. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Quine has long maintained in connection with his theses of under-determination of physical theory and indeterminacy of translation that there is a fact of the matter to physics but no fact of the matter to translation. In this paper, I investigate Quine's reasoning for this claim. I show that Quine's thinking about under-determination over the last twenty-five years has landed him in a contradiction: he says of two global physical theories that are empirically equivalent but logically incompatible that only one (...) is trueand that they are both true. In accord with the former position, I explain Quine'ssemantical argument for the claim that there is a fact of the matter to physics but not to translation. However, Quine has apparently come to regard this position as inconsistent with his empiricistic scruples: if both theories imply all and only true observation categoricals, then in what sense could one of them be false? Quine'strivial expedient argument construes such pairs of theories as merely two true descriptions of the same world in different terms. In accord with this latter position, I suggest that Quine is left without a way to differentiate under-determination and indeterminacy. In short, Quine's contradiction poses a serious dilemma: either only one such theory is true and his empiricism is sacrificed, or both theories are true and his distinction between under-determination and indeterminacy is sacrificed. (shrink)

SummaryQuine's doctrine of underdetermination of physical theory presents him with a dilemma: Should he say of two global theory formulations that are empirically equivalent, logically compatible, equally simple, but which cannot be rendered logically equivalent by any known reconstrual of predicates, that they are both true or that only one of them is true ? If the former, then Quine's commitment to naturalism is at risk; if the latter, then his commitment to empiricism is at risk. When confronted with the (...) dilemma Quine initially opted for the sectarian view. A.C. Genova finds Quine's sectarian resolution of the dilemma unsatisfactory. He advocates, instead, an ecumenical resolution of the dilemma which, he maintains, is compatible with Quine's most prominent views. I disagree; I argue that Genova's way out involves a relativistic notion of true that is incompatible with Quine's absolutist view of truth. I then present Quine's latest thoughts on the dilemma of underdetermination. (shrink)

I argue that thompson's analysis of the argument proscribing abortion except to save the woman's life is inconsistent, For it commits thompson to the following set of statements: (1) all fetuses have a right not to be killed unjustly; (2) no fetus can be aborted/killed unjustly unless it possesses a right to a woman's body; (3) some fetuses do not possess a right to a woman's body. I suggest two alternative ways to deal with this inconsistency.

In chapter 2 of The Fragmentation of Reason, Stephen Stich argues that certain passages of Quine’s Word and Object are the source of what he calls the conceptual argument. That argument claims there is a conceptual connection between intentionality and rationality: intentionality requires rationality. Stich rejects the idea that intentionality requires either perfect or fixed bridgehead rationality, but he concedes that it requires minimal rationality. After explaining Stich’s position and a criticism of it offered by John Biro and Kirk Ludwig, (...) I sketch an alternative to the conceptual argument. This alternative claims that rationality requires psychological plausibility and/or smoothness of communication, not rationality. (shrink)

Quine's conception of philosophy, his doctrine of naturalism, is analyzed as springing from a negative side, the rejection of first philosophy, through holism and unregenerate realism, and leading to an affirmative side, the acceptance of science as the ultimate instance. Quine's position is compared with Lauener's pragmatic or open transcendentalism, which is conventionalist and explicitiy nonnaturalistic but in spite of a whole string of differences nevertheless similar to the former. Finally a naturalistic position gains preference because it has more explanatory (...) power and a purely conventionalist account of logic (and mathematics) seems quite unrealistic. (shrink)

Quine's conception of philosophy, his doctrine of naturalism, is analyzed as springing from a negative side, the rejection of first philosophy, through holism and unregenerate realism, and leading to an affirmative side, the acceptance of science as the ultimate instance. Quine's position is compared with Lauener's pragmatic or open transcendentalism, which is conventionalist and explicitiy nonnaturalistic but in spite of a whole string of differences nevertheless similar to the former. Finally a naturalistic position gains preference because it has more explanatory (...) power and a purely conventionalist account of logic (and mathematics) seems quite unrealistic. (shrink)

This chapter contains sections titled: “Two Dogmas of Empiricism” “Two Dogmas of Empiricism” and Pragmatism.

Introduction: Variation across research ethics boards in conditions placed on access to medical records for research purposes raises concerns around negative impacts on research quality and on human subject protection, including privacy.Aim: To study variation in REB consent requirements for retrospective chart review and who may have access to the medical record for data abstraction.Methods: Thirty 90-min face-to-face interviews were conducted with REB chairs and administrators affiliated with faculties of medicine in Canadian universities, using structured questions around a case study (...) with open-ended responses. Interviews were recorded, transcribed and coded manually.Results: Fourteen sites required individual patient consent for the study to proceed as proposed. Three indicated that their response would depend on how potentially identifying variables would be managed. Eleven sites did not require consent. Two suggested a notification and opt-out process. Most stated that consent would be required if identifiable information was being abstracted from the record. Among those not requiring consent, there was substantial variation in recognising that the abstracted information could potentially indirectly re-identify individuals. Concern over access to medical records by an outside individual was also associated with requirement for consent. Eighteen sites required full committee review. Sixteen allowed an external research assistant to abstract information from the health record.Conclusions: Large variation was found across sites in the requirement for consent for research involving access to medical records. REBs need training in best practices for protecting privacy and confidentiality in health research. A forum for REB chairs to confidentially share concerns and decisions about specific studies could also reduce variation in decisions. (shrink)

Lipton articulates and defends a partial description of a central mechanism of inductive inference: Inference to the Best Explanation. IBE "is widely supposed to provide an accurate description of a central mechanism governing our [inductive] inferential practices and also a way to show why these practices are reliable". In spite of its popularity, however, IBE is little more than a slogan. "So it is time to flesh out the slogan and to give the model the detailed assessment it deserves. That (...) is the purpose of this book". (shrink)

This article examines the anonymous progymnasmata in John Doxapatres' commentary on Aphthonius' Progymnasmata for evidence about their authorship, origin, and relations to other progymnasmata. These exercises include three chreias, a refutation and confirmation of the myth of Ganymedes, an encomium and invective of Agamemnon, a comparison of the grapevine and olive tree, and an ethopoeia on the deposition of the emperor Michael V Kalaphates. In addition to providing a formal rhetorical analysis of the exercises, the article offers further support for (...) the view of R. F. Hock and E. N. O'Neil that Doxapatres did not compose these exercises and that they all derive from a single collection. In an appendix, it argues that George Pachymeres, in his comparison of the olive tree and grapevine, used the anonymous comparison in Doxapatres and not the four parallel exercises by Ps.-Nicolaus. (shrink)

Context: The dominant approach to the study of perception is representational/computational, with an emphasis on the achievements of the brain and the nervous system, which are taken to construct internal models of the world. Alternatives include ecological, embedded, embodied, and enactivist approaches, all of which emphasize the centrality of action in understanding perception. Problem: Despite sharing many theoretical commitments that lead to a rejection of the classical approach, the alternatives are characterized by important contrasts and points of divergence. Here we (...) focus on the enactive and ecological approaches, in particular, on how they construe the status of the environment and the content of perception. Method: We begin with a review of James Gibson’s ecological psychology, highlighting it as a psychology for all organisms not just humans. Against this backdrop, we consider enactivist arguments against direct perception - a central assertion of the ecological approach - and in favor of interpreting the activity of perceptual agents as a kind of construction of a perceptually meaningful world. Results: We assess the merits of this interpretation and we conclude that it cannot be grounded on fundamental principles such as thermodynamics and organism-environment mutuality. Implications: As a consequence, enactivism remains close to representationalism and entails a form of dualism. Constructivist content: We advance a criticism of the constructivist foundations of the enactive approach to perception. Perception-action mutuality at the heart of enactivism does not require mental construction; indeed, perception-action mutuality obviates construction. (shrink)

This article aims to offer a fresh analysis of two passages in the extensive necromancy episode in Lucan's Bellum Ciuile: the ritual to reanimate the dead soldier's corpse (6.667–73), and the surgical procedure Erichtho then proceeds to undertake (6.750–7), resembling the practice of a vivisection. The study will focus mostly on the strong connection of magic to medical traditions in antiquity, with a commentary on, and analysis of, these verses through the lenses of medical vocabulary, themes and motifs. It ultimately (...) concludes that Lucan was familiar with the language and characteristics of the medical tradition, enriched his report with them, and was playing with his audience's knowledge of the same. (shrink)

Ch. 1. Problemy metodologii issledovanii︠a︡ nravstvennogo ideala russkoĭ filosofii -- ch. 2. Personalia. Nravstvennye iskanii︠a︡ russkikh mysliteleĭ.